BDBM50559076 CHEMBL4743159

SMILES CC(C)C(=O)Nc1nc(cs1)-c1ccc(O)cc1O

InChI Key InChIKey=WIDNAJNXDPHROL-UHFFFAOYSA-N

Data  3 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50559076   

TargetTyrosinase(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human his tagged tyrosinase expressed in HEK293 cells using L-DOPA as substrate by HTS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataIC50: 108nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate by HTS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPolyphenol oxidase 4(Agaricus bisporus)
North-West University

Curated by ChEMBL
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataIC50: 130nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTyrosinase(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataIC50: 170nMAssay Description:Inhibition of tyrosinase in human MNT-1 cells using L-DOPA as substrate preincubated for 10 mins followed by substrate addition measured after 180 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosinase(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataKi:  250nMAssay Description:Binding affinity to His-tagged human tyrosinase expressed in HEK293 cells assessed as inhibition constant by HTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosinase(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataKi:  250nMAssay Description:Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataKi:  250nMAssay Description:Competitive inhibition of His-tagged human tyrosinase expressed in HEK293 cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosinase(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataKi:  250nMAssay Description:Inhibition of truncated His-tagged human tyrosinase catalytic domain expressed in HEK293 cells using L-DOPA as substrate assessed as inhibition const...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosinase(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataKi:  250nMAssay Description:Binding affinity to human His-tagged tyrosinase CD expressed in HEK293 cells assessed as inhibition constant using L-DOPA as substrate by HTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTyrosinase(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataIC50: 900nMAssay Description:Inhibition of human His-tagged tyrosinase CD expressed in HEK293 cells assessed as inhibition of melanin production using L-DOPA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTyrosinase(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataKi:  920nMAssay Description:Binding affinity to human tyrosinase using l-DOPA as substrate assessed as inhibition constant by Michaelis-Menten plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosinase(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataIC50: 1.10E+3nMAssay Description:Competitive inhibition of human tyrosinase using L-DOPA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTyrosinase(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of truncated His-tagged human tyrosinase catalytic domain expressed in HEK293 cells using L-DOPA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetTyrosinase(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataIC50: 1.10E+3nMAssay Description:Competitive inhibition of His-tagged human tyrosinase expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosinase(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human tyrosinase using L-DOPA as substrate incubated for 10 to 20 mins by MBTH dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTyrosinase(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human tyrosinase assessed as reduction in L-dopaquinone-MBTH complex formation using L-DOPA as substrate measured for 10 mins by spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human tyrosinase using L-DOPA as substrate by spectrophotometer analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPolyphenol oxidase 4(Agaricus bisporus)
North-West University

Curated by ChEMBL
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataIC50: 1.08E+5nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate by spectrophotometer analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed