BDBM50560784 CHEMBL4787000

SMILES Cc1cc(Nc2ccc3nccnc3c2)nc(n1)-c1ccccc1

InChI Key InChIKey=JABWTQGZBCXHAC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50560784   

TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Rheinische Friedrich-Wilhelms-University Bonn

Curated by ChEMBL
LigandPNGBDBM50560784(CHEMBL4787000)
Affinity DataIC50: 312nMAssay Description:Inhibition of human ABCG2 expressed in MDCK2 cells co-expressing GFP preincubated for 15 mins followed by pheophorbideA addition and measured after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Rheinische Friedrich-Wilhelms-University Bonn

Curated by ChEMBL
LigandPNGBDBM50560784(CHEMBL4787000)
Affinity DataIC50: 1.34E+4nMAssay Description:Inhibition of human ABCB1 expressed in A2780/ADR cells preincubated for 30 mins followed by calcein AM addition and measured every 60 secs for 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Rheinische Friedrich-Wilhelms-University Bonn

Curated by ChEMBL
LigandPNGBDBM50560784(CHEMBL4787000)
Affinity DataIC50: 2.84E+4nMAssay Description:Inhibition of human ABCC1 expressed in MDCK2 cells preincubated for 30 mins followed by calcein AM addition and measured every 60 secs for 60 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed