BDBM50560791 CHEMBL4740157

SMILES COc1cc(OCc2ccnc(Nc3cnn(C)c3)n2)c(Cl)c2sc(N[C@H]3CCCC[C@@H]3O)nc12

InChI Key InChIKey=JYFJGEOXSQLPMB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50560791   

TargetMacrophage colony-stimulating factor 1 receptor(Human)
University of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50560791(CHEMBL4740157)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Mouse)
University of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50560791(CHEMBL4740157)
Affinity DataIC50: 14nMAssay Description:Inhibition of CSF1R in mouse NFS-60 cells assessed as reduction in CSF-induced cell proliferation after 72 hrs by CellTiter-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed