BDBM50560810 CHEMBL4798920

SMILES Nc1nccc(COc2cc(OC(F)(F)F)c3nc(N[C@@H]4CCCC[C@H]4O)sc3c2)c1Cl

InChI Key InChIKey=KAROEHNWLQYYAB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50560810   

TargetMacrophage colony-stimulating factor 1 receptor(Human)
University of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50560810(CHEMBL4798920)
Affinity DataIC50: 17nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Mouse)
University of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50560810(CHEMBL4798920)
Affinity DataIC50: 930nMAssay Description:Inhibition of CSF1R in mouse NFS-60 cells assessed as reduction in CSF-induced cell proliferation after 72 hrs by CellTiter-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed