BDBM50561219 CHEMBL4782125::US11377469, Example 13

SMILES O[C@@H]1[C@@H](CSCP(O)(O)=O)O[C@H]([C@@H]1O)n1ncc2c(NCc3ccccc3Cl)nc(Cl)nc12

InChI Key InChIKey=JAIAGXYPLMOWIL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50561219   

Target5'-nucleotidase(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561219(CHEMBL4782125 | US11377469, Example 13)
Affinity DataIC50: 164nMAssay Description:Inhibition of human C-terminal His6-tagged CD73 expressed in CHO cells preincubated for 15 mins followed by AMP addition and measured after 10 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561219(CHEMBL4782125 | US11377469, Example 13)
Affinity DataIC50: 500nMAssay Description:Assay Reaction ConditionsAssay Volume: 70 μlReaction Volume: 50 μlCD73: 0.3208 nMAMP: 15 μMAssay Buffer: 2 5 mM Tris-HCL, pH 7.4, 0.01...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2022
Entry Details
US Patent