BDBM50561230 CHEMBL4784951::US11325938, Ex 194

SMILES CC(CO)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ncc2c(NC3CCCC3)nc(Cl)nc12)P(O)(O)=O

InChI Key InChIKey=DWPITEDBCBAYRP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50561230   

Target5'-nucleotidase(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561230(CHEMBL4784951 | US11325938, Ex 194)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human C-terminal His6-tagged CD73 expressed in CHO cells preincubated for 15 mins followed by AMP addition and measured after 10 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561230(CHEMBL4784951 | US11325938, Ex 194)
Affinity DataIC50: 100nMAssay Description:Assay Reaction ConditionsAssay Volume: 70 μlReaction Volume: 50 μlCD73: 0.3208 nMAMP: 15 μMAssay Buffer: 25 mM Tris-HCL, pH 7.4, 0.01%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2022
Entry Details
US Patent

Target5'-nucleotidase(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561230(CHEMBL4784951 | US11325938, Ex 194)
Affinity DataIC50: 100nMAssay Description:Assay Reaction ConditionsAssay Volume: 70 μlReaction Volume: 50 μlCD73: 0.3208 nMAMP: 15 μMAssay Buffer: 25 mM Tris-HCL, pH 7.4, 0.01%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2022
Entry Details
US Patent