BDBM50561737 CHEMBL4788632

SMILES [H][C@]12CC[C@]([H])(CN(C1)c1cc(C)ncn1)[C@H]2Nc1nc2[C@@H](CCCn2n1)Oc1ccc(Cl)cc1

InChI Key InChIKey=MJLRPASHEJEXBJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50561737   

TargetPresenilin-1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50561737(CHEMBL4788632 | US12195470, Example 45)
Affinity DataIC50: 10nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50561737(CHEMBL4788632 | US12195470, Example 45)
Affinity DataIC50: 10.3nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent