BDBM50562541 CHEMBL4783744

SMILES O=C(C1CC1)c1ccc(OCCCN2CCN(CC2)c2ccncc2)cc1

InChI Key InChIKey=MHFUOIGTIQCKRH-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50562541   

TargetHistamine H3 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50562541(CHEMBL4783744)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from recombinant human histamine H3 receptor stably expressed in HEK293 cells assessed as inhibition const...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistamine H3 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50562541(CHEMBL4783744)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]UR-PI294 from human SP-FLAG-tagged H3R expressed in HEK293T cells measured after 60 to 120 mins by liquid scintillation counting ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50562541(CHEMBL4783744)
Affinity DataKi:  101nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor in Sprague-Dawley rat liver assessed as inhibition constant by liquid scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50562541(CHEMBL4783744)
Affinity DataKi:  1.53E+3nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane assessed as inhibition constant by liquid scintillation counte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistamine H1 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50562541(CHEMBL4783744)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]mepyramine from human H1R expressed in Sf9 cell membranes co-expressing RGS4 measured after 60 mins by scintillation counting ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50562541(CHEMBL4783744)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]histamine from Gialpha2/Gbeta1gamma2-coupled human H4R expressed in Sf9 cell membranes measured after 60 mins by scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50562541(CHEMBL4783744)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]UR-DE257 from Gsalphas-coupled human H2R expressed in Sf9 cell membranes measured after 60 mins by scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed