BDBM50562994 CHEMBL4740532

SMILES Cc1nnn(C)c1-c1cc(Br)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl

InChI Key InChIKey=GIDGCOVAJNOCKD-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50562994   

TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50562994(CHEMBL4740532)
Affinity DataKi:  2nMAssay Description:Inhibition of wild type EZH2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50562994(CHEMBL4740532)
Affinity DataKi:  7nMAssay Description:Inhibition of wild type EZH2 Y641N mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50562994(CHEMBL4740532)
Affinity DataIC50:  30nMAssay Description:Inhibition of wild type EZH2 in human KARPAS-422 cells assessed as effect on H3K27Me3 levelsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed