BDBM50563253 CHEMBL4750601

SMILES COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccc2nccc(\C(C)=C\C(=O)N3CCC(O)CC3)c2c1

InChI Key InChIKey=HDIJQWUAQYTOQE-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50563253   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Jiaxing University

Curated by ChEMBL

LigandBDBM50563253(CHEMBL4750601)Copy SMILESCopy InChI

Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant human PI3Kalpha using PIP2 as substrate incubated for 1 hr by kinase-glo luminescent assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/29/2022
Entry Details Article
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TargetSerine/threonine-protein kinase mTOR(Human)
Jiaxing University

Curated by ChEMBL

LigandBDBM50563253(CHEMBL4750601)Copy SMILESCopy InChI

Affinity DataIC50: 6.10nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged mTOR (1362 to end amino acids) using ULight-4E-BP1 as substrate incubated for 1 hr by LANCE Ul...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/29/2022
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL