BDBM50564458 CHEMBL4788376

SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(CCC#N)cc23)c1C

InChI Key InChIKey=PIPKBPQXMOCACO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50564458   

Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50564458(CHEMBL4788376 | US12435059, Compound 15)
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human His6-tagged AMPK alpha2 using ULight CRBtide as substrate incubated for 1 hr followed by substrate addition and measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50564458(CHEMBL4788376 | US12435059, Compound 15)
Affinity DataIC50: 32.4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Target5'-AMP-activated protein kinase catalytic subunit alpha-1(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50564458(CHEMBL4788376 | US12435059, Compound 15)
Affinity DataIC50: 164nMAssay Description:Inhibition of recombinant human His6-tagged AMPK alpha1 using ULight CRBtide as substrate incubated for 1 hr followed by substrate addition and measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
Target5'-AMP-activated protein kinase catalytic subunit alpha-1(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50564458(CHEMBL4788376 | US12435059, Compound 15)
Affinity DataIC50: 164nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50564458(CHEMBL4788376 | US12435059, Compound 15)
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of tracer 236 binding to recombinant human N-terminal GST-tagged full length KDR (790 to 1356 residues) expressed in baculovirus expressio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL
LigandPNGBDBM50564458(CHEMBL4788376 | US12435059, Compound 15)
Affinity DataIC50: 1.33E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent