BDBM50567686 CHEMBL4798975

SMILES NS(=O)(=O)c1ccc(cc1)-c1cnc2[nH]nc(C(=O)c3c(F)ccc(NS(=O)(=O)Cc4ccccc4)c3F)c2c1

InChI Key InChIKey=OGNOHOPSWWOASA-UHFFFAOYSA-N

Data  1 IC50  6 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50567686   

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Eberhard Karls Universit£T

Curated by ChEMBL
LigandPNGBDBM50567686(CHEMBL4798975)
Affinity DataKd:  1.70nMAssay Description:Binding affinity to wild-type human partial length MKK4 (S84 to D399 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Eberhard Karls Universit£T

Curated by ChEMBL
LigandPNGBDBM50567686(CHEMBL4798975)
Affinity DataIC50: 146nMAssay Description:Inhibition of MKK4 (unknown origin) by PanQinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Eberhard Karls Universit£T

Curated by ChEMBL
LigandPNGBDBM50567686(CHEMBL4798975)
Affinity DataKd:  210nMAssay Description:Binding affinity to wild-type human full length JNK1 (M1 to Q384 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Eberhard Karls Universit£T

Curated by ChEMBL
LigandPNGBDBM50567686(CHEMBL4798975)
Affinity DataKd:  450nMAssay Description:Binding affinity to wild-type human partial length BRAF (S429 to E741 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 5(Human)
Eberhard Karls Universit£T

Curated by ChEMBL
LigandPNGBDBM50567686(CHEMBL4798975)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to wild-type human partial length MAP4K5 (M1 to P297 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Eberhard Karls Universit£T

Curated by ChEMBL
LigandPNGBDBM50567686(CHEMBL4798975)
Affinity DataKd:  5.00E+3nMAssay Description:Binding affinity to wild-type human full length MKK7 (M1 to R419 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 20(Human)
Eberhard Karls Universit£T

Curated by ChEMBL
LigandPNGBDBM50567686(CHEMBL4798975)
Affinity DataKd:  5.00E+3nMAssay Description:Binding affinity to wild-type human partial length ZAK (M1 to L331 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed