BDBM50567998 CHEMBL4876457::US11903936, Compound 26

SMILES CC(NC(=O)c1[nH]cc(c1C)C1(CC1)c1ccc(c(c1)C#N)C(F)(F)F)c1nc[nH]n1

InChI Key InChIKey=QOYSJYDAYLKBNM-UHFFFAOYSA-N

Data  12 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50567998   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Texas

US Patent
LigandPNGBDBM50567998(CHEMBL4876457 | US11903936, Compound 26)
Affinity DataEC50:  6.40nMAssay Description:P. falciparum 3D7 cells were grown in RPMI media supplemented with 0.5% albuMAX I, human red blood cells to 0.5% hematocrit and 0.5% parasitemia as d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(malaria parasite P. vivax)
University of Texas

US Patent
LigandPNGBDBM50567998(CHEMBL4876457 | US11903936, Compound 26)
Affinity DataIC50: 74nMAssay Description:The 50% inhibitory concentration (IC50) for the described compounds was determined using the 2,6-dichloroindophenol (DCIP) assay to monitor the DHODH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Texas

US Patent
LigandPNGBDBM50567998(CHEMBL4876457 | US11903936, Compound 26)
Affinity DataIC50: 96nMAssay Description:The 50% inhibitory concentration (IC50) for the described compounds was determined using the 2,6-dichloroindophenol (DCIP) assay to monitor the DHODH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
US Patent

TargetSubstance-P receptor(Human)
Medicines For Malaria Venture

Curated by ChEMBL
LigandPNGBDBM50567998(CHEMBL4876457 | US11903936, Compound 26)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of NK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Medicines For Malaria Venture

Curated by ChEMBL
LigandPNGBDBM50567998(CHEMBL4876457 | US11903936, Compound 26)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin) by UPLC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Medicines For Malaria Venture

Curated by ChEMBL
LigandPNGBDBM50567998(CHEMBL4876457 | US11903936, Compound 26)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin) by UPLC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Medicines For Malaria Venture

Curated by ChEMBL
LigandPNGBDBM50567998(CHEMBL4876457 | US11903936, Compound 26)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin) by UPLC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Medicines For Malaria Venture

Curated by ChEMBL
LigandPNGBDBM50567998(CHEMBL4876457 | US11903936, Compound 26)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) by UPLC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Medicines For Malaria Venture

Curated by ChEMBL
LigandPNGBDBM50567998(CHEMBL4876457 | US11903936, Compound 26)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin) using phenacetin O-deethylation by UPLC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Medicines For Malaria Venture

Curated by ChEMBL
LigandPNGBDBM50567998(CHEMBL4876457 | US11903936, Compound 26)
Affinity DataIC50: 2.04E+4nMAssay Description:Inhibition of human ERG by QPatch assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
University of Texas

US Patent
LigandPNGBDBM50567998(CHEMBL4876457 | US11903936, Compound 26)
Affinity DataIC50: 1.00E+5nMAssay Description:The 50% inhibitory concentration (IC50) for the described compounds was determined using the 2,6-dichloroindophenol (DCIP) assay to monitor the DHODH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
University of Texas

US Patent
LigandPNGBDBM50567998(CHEMBL4876457 | US11903936, Compound 26)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human DHODH expressed in Escherichia coli BL21-DE3 using L-dihydroorotate as substrate by steady-state DCIP methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
University of Texas

US Patent
LigandPNGBDBM50567998(CHEMBL4876457 | US11903936, Compound 26)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human DHODH expressed in Escherichia coli BL21-DE3 using L-dihydroorotate as substrate by steady-state DCIP methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed