BDBM50568639 CHEMBL4846243

SMILES [H][C@@]12C[C@@]3([H])C(CN1CC[C@@]14c5ccccc5N(C)[C@@]21OC[C@]34C(=O)OC)=CC

InChI Key

Data  9 KI  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50568639   

TargetMu-type opioid receptor(Human)
University of Illinois Chicago

Curated by ChEMBL
LigandPNGBDBM50568639(CHEMBL4846243)
Affinity DataKi:  330nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) assessed as inhibition constant incubated for 180 mins by competitive radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
University of Illinois Chicago

Curated by ChEMBL
LigandPNGBDBM50568639(CHEMBL4846243)
Affinity DataKi:  590nMAssay Description:Displacement of [3H]-DAMGO from human mu opioid receptor expressed in CHO-K1 cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Illinois Chicago

Curated by ChEMBL
LigandPNGBDBM50568639(CHEMBL4846243)
Affinity DataKi:  631nMAssay Description:Displacement of [3H]-DAMGO from human mu opioid receptor expressed in CHO-K1 cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50568639(CHEMBL4846243)
Affinity DataKi:  2.25E+3nMAssay Description:Displacement of [3H]-U69593 from human kappa opioid receptor expressed in U2OS cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50568639(CHEMBL4846243)
Affinity DataKi:  2.25E+3nMAssay Description:Displacement of [3H]-U69593 from human kappa opioid receptor expressed in U2OS cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50568639(CHEMBL4846243)
Affinity DataKi:  2.25E+3nMAssay Description:Displacement of [3H]-U69593 from kappa opioid receptor (unknown origin) assessed as inhibition constant incubated for 180 mins by competitive radioli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50568639(CHEMBL4846243)
Affinity DataIC50: 5.01E+3nMAssay Description:Agonist activity at mouse HA-tagged mu opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP production preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50568639(CHEMBL4846243)
Affinity DataEC50:  5.24E+3nMAssay Description:Agonist activity at HA-tagged mouse mu opioid receptor expressed in human HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50568639(CHEMBL4846243)
Affinity DataIC50: 5.24E+3nMAssay Description:Agonist activity at mouse HA-tagged mu opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP production preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50568639(CHEMBL4846243)
Affinity DataIC50: 6.31E+3nMAssay Description:Agonist activity at mouse FLAG-tagged kappa opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP production pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50568639(CHEMBL4846243)
Affinity DataIC50: 6.46E+3nMAssay Description:Agonist activity at mouse FLAG-tagged kappa opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP production pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50568639(CHEMBL4846243)
Affinity DataKi:  7.94E+3nMAssay Description:Displacement of [3H]-DPDPE from human delta opioid receptor expressed in CHO-K1 cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50568639(CHEMBL4846243)
Affinity DataKi:  8.37E+3nMAssay Description:Displacement of [3H]-DPDPE from human delta opioid receptor expressed in CHO-K1 cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50568639(CHEMBL4846243)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-SCH23390 from dopamine D5 receptor (unknown origin) expressed in HEK-293T cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50568639(CHEMBL4846243)
Affinity DataIC50: 9.56E+4nMAssay Description:Agonist activity at mouse FLAG-tagged delta opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP production pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed