BDBM50568724 CHEMBL4850231

SMILES COc1cc(cc2sc(NC(=O)c3[nH]c(C)c(Cl)c3Cl)nc12)C(O)=O

InChI Key InChIKey=WWSSIVALOHLUTG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50568724   

TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Univerza V Ljubljani

US Patent
LigandPNGBDBM50568724(CHEMBL4850231 | US12258342, Example 8)
Affinity DataIC50: 7.60nMAssay Description:First, the plates were rehydrated with buffer (20 mM Tris-HCl with pH 7.6, 0.01% w/v BSA, 0.05% v/v Tween 20, 137 mM NaCl) and the biotinylated oligo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2025
Entry Details
US Patent

TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Univerza V Ljubljani

US Patent
LigandPNGBDBM50568724(CHEMBL4850231 | US12258342, Example 8)
Affinity DataIC50: 10nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as reduction in relaxation of supercoiled pNO1 DNA measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50568724(CHEMBL4850231 | US12258342, Example 8)
Affinity DataIC50: 44nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase assessed reduction in relaxation of supercoiled pNO1 DNA measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed