BDBM50568732 CHEMBL4871682

SMILES Cc1[nH]c(C(=O)Nc2nc3c(OCc4cccc(F)c4)cc(cc3s2)C(O)=O)c(Cl)c1Cl

InChI Key InChIKey=HZBPDEAJTXOHLM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50568732   

TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Univerza V Ljubljani

US Patent
LigandPNGBDBM50568732(CHEMBL4871682 | US12258342, Example 30)
Affinity DataIC50: 5nMAssay Description:First, the plates were rehydrated with buffer (20 mM Tris-HCl with pH 7.6, 0.01% w/v BSA, 0.05% v/v Tween 20, 137 mM NaCl) and the biotinylated oligo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2025
Entry Details
US Patent

TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Univerza V Ljubljani

US Patent
LigandPNGBDBM50568732(CHEMBL4871682 | US12258342, Example 30)
Affinity DataIC50: 10nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as reduction in relaxation of supercoiled pNO1 DNA measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetDNA gyrase subunit B(Escherichia coli)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50568732(CHEMBL4871682 | US12258342, Example 30)
Affinity DataIC50: 10nMAssay Description:Inhibition of Escherichia coli full length wildtype GyrB24 (residue 1 to 220) supercoiling in presence of pNO1 plasmid incubated for 30 mins by micro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50568732(CHEMBL4871682 | US12258342, Example 30)
Affinity DataIC50: 10nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase assessed reduction in relaxation of supercoiled pNO1 DNA measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed