BDBM50569345 CHEMBL4876909

SMILES CC1(Cc2ccncc2C(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F

InChI Key InChIKey=JKGKDTCSFLEUTI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50569345   

TargetBeta-secretase 1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50569345(CHEMBL4876909)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells expressing APP assessed as reduction in Abeta40 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50569345(CHEMBL4876909)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of BACE1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed