BDBM50569348 CHEMBL4856179

SMILES CC1(Cc2cnccc2C(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F

InChI Key InChIKey=JOHPZDTZXLXEQE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50569348   

TargetBeta-secretase 1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50569348(CHEMBL4856179)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells expressing APP assessed as reduction in Abeta40 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50569348(CHEMBL4856179)
Affinity DataIC50: 21nMAssay Description:Inhibition of BACE1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed