BDBM50569443 CHEMBL4851179

SMILES Clc1ccc(cc1)S(=O)(=O)N(Nc1cccc(Cl)c1)C(=O)Oc1ccc(OCc2ccccc2)cc1

InChI Key InChIKey=RMSNLMYIWIRKKV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50569443   

TargetProstaglandin E synthase(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50569443(CHEMBL4851179)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human mPGES-1 assessed as reduction in PGE2 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetProstaglandin E synthase(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50569443(CHEMBL4851179)
Affinity DataIC50: 150nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as reduction in IL-1beta stimulated PGE2 production incubated for 24 hrs by EIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50569443(CHEMBL4851179)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of mPGES-1 activity in IL-1beta stimulated human A549 cells microsomes assessed as reduction in PGE2 production preincubated for 15 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed