BDBM50569506 CHEMBL1520901::US11452717, Compound TableB-2.28

SMILES CCOC(=O)c1ccc(NC(=O)NCc2ccncc2)cc1

InChI Key InChIKey=LNIPYBUMGBKFKQ-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50569506   

TargetNicotinamide phosphoribosyltransferase(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569506(CHEMBL1520901 | US11452717, Compound TableB-2.28)
Affinity DataEC50:  3.25E+3nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569506(CHEMBL1520901 | US11452717, Compound TableB-2.28)
Affinity DataEC50:  3.25E+3nMAssay Description:Activation of N-terminal His-tagged human NAMPT expressed in Escherichia coli BL 21 (DE3) using NAM and PRPP as substrates incubated for 15 mins in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569506(CHEMBL1520901 | US11452717, Compound TableB-2.28)
Affinity DataEC50:  3.30E+3nMAssay Description:Activation of human NAMPT assessed as increase in NMN production by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569506(CHEMBL1520901 | US11452717, Compound TableB-2.28)
Affinity DataEC50:  3.50E+3nMAssay Description:NAMPT reaction was performed in 50 mM HEPES, pH 7.5, containing 5 mM MgCl2, 0.1% Prionex, 0.005% Tween 20, and 1 mM TCEP at room temperature in Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569506(CHEMBL1520901 | US11452717, Compound TableB-2.28)
Affinity DataEC50: >2.00E+4nMAssay Description:NAMPT reaction was performed in 50 mM HEPES, pH 7.5, containing 5 mM MgCl2, 0.1% Prionex, 0.005% Tween 20, and 1 mM TCEP at room temperature in Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
US Patent