BDBM50569664 CHEMBL4859451

SMILES COc1ccccc1Nc1nc(Nc2cc3CN(C)CCc3cc2OC)ncc1C(N)=O

InChI Key InChIKey=GSPLKKLFDPBGPY-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50569664   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Merck

Curated by ChEMBL

LigandBDBM50569664(CHEMBL4859451)Copy SMILESCopy InChI

Affinity DataIC50: 0.00500nMAssay Description:Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/20/2022
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Merck

Curated by ChEMBL

LigandBDBM50569664(CHEMBL4859451)Copy SMILESCopy InChI

Affinity DataIC50: 0.0100nMAssay Description:Inhibition of human HPK1 catalytic domain (1 to 346 residues) using His-tagged SLP76 as substrate assessed as reduction in substrate phosphorylation ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/18/2024
Entry Details
Copy BDB DOIPubMed
Copy reaction URL