BDBM50570570 CHEMBL4874266

SMILES CC(C)(C)c1cccc(CNC[C@@H](O)[C@H](Cc2ccccc2)NC(=O)C(c2ccccc2)c2ccccc2)c1

InChI Key InChIKey=FDZZTBAHBJUANF-AJQTZOPKSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50570570   

TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50570570(CHEMBL4874266)
Affinity DataIC50:  2.86E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine as substrate preincubated for 5 mins followed by substrate addition and measured after 5 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50570570(CHEMBL4874266)
Affinity DataIC50:  60nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine as substrate preincubated for 5 mins followed by substrate addition and measured after 5 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mus musculus)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50570570(CHEMBL4874266)
Affinity DataIC50:  1.91E+4nMAssay Description:Inhibition of mouse GAT2 expressed in HEK293 cell line assessed as reduction in [3H]GABA uptake incubated for 10 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50570570(CHEMBL4874266)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of recombinant human BACE1 expressed in baculovirus expression system using Rh-EVNLDAEFK-quencher as substrate incubated for 60 mins by FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50570570(CHEMBL4874266)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cell line assessed as reduction in [3H]GABA uptake incubated for 10 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50570570(CHEMBL4874266)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BuchE using butyrylthiocholine as substrate preincubated for 5 mins followed by substrate addition and measured after 5 mins by E...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed