BDBM50571446 CHEMBL4879094

SMILES COc1ccc2c(c1)Cc1cccc(-c3cc(N4CCOCC4)cc(=O)[nH]3)c1S2

InChI Key InChIKey=OEWUSAJPHBVLOD-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50571446   

TargetSerine-protein kinase ATM(Human)
Charles River

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50571446BDBM50571446(CHEMBL4879094)
Affinity DataKi:  4nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50571446BDBM50571446(CHEMBL4879094)
Affinity DataKi:  130nMAssay Description:Inhibition of full length recombinant GST-tagged human VPS34 expressed in baculovirus expression system using PI/PS as substrate incubated for 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Charles River

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50571446BDBM50571446(CHEMBL4879094)
Affinity DataIC50: 880nMAssay Description:Inhibition of ATM in human U2OS cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation incubated for 60 mins by immunoreactivity as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed