BDBM50571448 CHEMBL4872482

SMILES COc1ccc2c(c1)Cc1cccc(-c3cc(=O)cc(N4CCOCC4)[nH]3)c1S2

InChI Key InChIKey=VLHOFEKDBPRRKV-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50571448   

TargetSerine-protein kinase ATM(Human)
Charles River

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50571448BDBM50571448(CHEMBL4872482)
Affinity DataKi:  110nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Charles River

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50571448BDBM50571448(CHEMBL4872482)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of ATM in human U2OS cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation incubated for 60 mins by immunoreactivity as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed