BDBM50571455 CHEMBL4873212::US11685734, Example 1

SMILES O=c1cc(cc([nH]1)N1CCC[C@@H]1Cc1ccccc1)N1CCOCC1

InChI Key InChIKey=NUUYFIBMHLLMSL-QGZVFWFLSA-N

Data  2 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50571455   

TargetSerine-protein kinase ATM(Human)
Charles River

Curated by ChEMBL
LigandPNGBDBM50571455(CHEMBL4873212 | US11685734, Example 1)
Affinity DataKi:  6nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
LigandPNGBDBM50571455(CHEMBL4873212 | US11685734, Example 1)
Affinity DataKi:  9nMAssay Description:Inhibition of full length recombinant GST-tagged human VPS34 expressed in baculovirus expression system using PI/PS as substrate incubated for 60 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSerine-protein kinase ATM(Human)
Charles River

Curated by ChEMBL
LigandPNGBDBM50571455(CHEMBL4873212 | US11685734, Example 1)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of ATM in human U2OS cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation incubated for 60 mins by immunoreactivity as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Human)
Charles River

Curated by ChEMBL
LigandPNGBDBM50571455(CHEMBL4873212 | US11685734, Example 1)
Affinity DataIC50:  36.2nMAssay Description:ATM: Recombinant, full length human FLAG-tagged ATM activity (Eurofins 14-933) was measured in an ELISA for p53 S15 phosphorylation, in a 384 well V-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent