BDBM50571464 CHEMBL4874640::US11685734, Example 43

SMILES [H][C@]12C[C@@]1([H])[C@H](Cc1ccccc1)N(C2)c1cc(cc(=O)[nH]1)N1CCOCC1

InChI Key InChIKey=FZLLSBHPQYLGLH-QRQLOZEOSA-N

Data  3 KI  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50571464   

TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571464(CHEMBL4874640 | US11685734, Example 43)
Affinity DataKi:  2nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571464(CHEMBL4874640 | US11685734, Example 43)
Affinity DataKi:  98nMAssay Description:Inhibition of full length recombinant GST-tagged human VPS34 expressed in baculovirus expression system using PI/PS as substrate incubated for 60 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571464(CHEMBL4874640 | US11685734, Example 43)
Affinity DataKi:  180nMAssay Description:Inhibition of DNA-PK isolated from human HeLa nuclear extract using full length His-tagged p53 as substrate measured after 75 mins in presence of ATP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571464(CHEMBL4874640 | US11685734, Example 43)
Affinity DataIC50:  290nMAssay Description:Inhibition of ATM in human U2OS cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation incubated for 60 mins by immunoreactivity as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571464(CHEMBL4874640 | US11685734, Example 43)
Affinity DataKd:  4.60E+3nMAssay Description:Binding affinity to mTOR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571464(CHEMBL4874640 | US11685734, Example 43)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of ATR in human HT-29 cells assessed as reduction in CHK1 phosphorylation incubated for 4 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Charles River

Curated by ChEMBL
LigandPNGBDBM50571464(CHEMBL4874640 | US11685734, Example 43)
Affinity DataIC50:  9.60nMAssay Description:ATM: Recombinant, full length human FLAG-tagged ATM activity (Eurofins 14-933) was measured in an ELISA for p53 S15 phosphorylation, in a 384 well V-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent