BDBM50571470 CHEMBL4869283::US11685734, Example 41

SMILES C[C@@H]1CN(c2cc(N3C[C@H]4C[C@H]4[C@@H]3Cc3ccccc3)[nH]c(=O)c2)CCO1

InChI Key InChIKey=GCKKBGHFJIZIAB-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50571470   

TargetSerine-protein kinase ATM(Human)
Charles River

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50571470BDBM50571470(CHEMBL4869283 | US11685734, Example 41)
Affinity DataKi:  11nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Charles River

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50571470BDBM50571470(CHEMBL4869283 | US11685734, Example 41)
Affinity DataIC50: 69.1nMAssay Description:ATM: Recombinant, full length human FLAG-tagged ATM activity (Eurofins 14-933) was measured in an ELISA for p53 S15 phosphorylation, in a 384 well V-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

TargetSerine-protein kinase ATM(Human)
Charles River

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50571470BDBM50571470(CHEMBL4869283 | US11685734, Example 41)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ATM in human U2OS cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation incubated for 60 mins by immunoreactivity as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50571470BDBM50571470(CHEMBL4869283 | US11685734, Example 41)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of full length recombinant GST-tagged human VPS34 expressed in baculovirus expression system using PI/PS as substrate incubated for 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed