BDBM50571475 CHEMBL4853948::US11685734, Example 292

SMILES C[C@@H]1CN(c2cc(=O)[nH]c(N3C[C@@H]4C[C@@H]4[C@@H]3Cc3ccccc3)n2)CCO1

InChI Key InChIKey=KREZBWKMMRSYDH-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50571475   

TargetSerine-protein kinase ATM(Human)
Charles River

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50571475BDBM50571475(CHEMBL4853948 | US11685734, Example 292)
Affinity DataKi:  0.900nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Charles River

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50571475BDBM50571475(CHEMBL4853948 | US11685734, Example 292)
Affinity DataIC50: 5.5nMAssay Description:ATM: Recombinant, full length human FLAG-tagged ATM activity (Eurofins 14-933) was measured in an ELISA for p53 S15 phosphorylation, in a 384 well V-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

TargetSerine-protein kinase ATM(Human)
Charles River

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50571475BDBM50571475(CHEMBL4853948 | US11685734, Example 292)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of ATM in human U2OS cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation incubated for 60 mins by immunoreactivity as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50571475BDBM50571475(CHEMBL4853948 | US11685734, Example 292)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of full length recombinant GST-tagged human VPS34 expressed in baculovirus expression system using PI/PS as substrate incubated for 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed