BDBM50571477 CHEMBL4869059

SMILES Cc1c(NC(=O)CCN2CCCC2)c[nH]c1\C=C1/C(=O)Nc2ccc(F)cc12

InChI Key InChIKey=WSCLCZKFOUHIBA-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50571477   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50571477(CHEMBL4869059)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin) incubated for 30 mins in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50571477(CHEMBL4869059)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of FLT3 (unknown origin) incubated for 30 mins in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50571477(CHEMBL4869059)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin) incubated for 30 mins in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50571477(CHEMBL4869059)
Affinity DataIC50: 13nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin) expressed in mouse BaF3 cells assessed as antiproliferative activity incubated for 72 hrs by CCK8 assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50571477(CHEMBL4869059)
Affinity DataIC50: 27nMAssay Description:Inhibition of FLT3 ITD/D835V double mutant (unknown origin) expressed in mouse BaF3 cells assessed as antiproliferative activity incubated for 72 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50571477(CHEMBL4869059)
Affinity DataIC50: 30nMAssay Description:Inhibition of TEL-FLT3 D835V mutant (unknown origin) expressed in mouse BaF3 cells assessed as antiproliferative activity incubated for 72 hrs by CCK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50571477(CHEMBL4869059)
Affinity DataIC50: 37nMAssay Description:Inhibition of TEL-FLT3 D835Y mutant (unknown origin) expressed in mouse BaF3 cells assessed as antiproliferative activity incubated for 72 hrs by CCK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50571477(CHEMBL4869059)
Affinity DataIC50: 37nMAssay Description:Inhibition of FLT3 ITD/D835Y double mutant (unknown origin) expressed in mouse BaF3 cells assessed as antiproliferative activity incubated for 72 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50571477(CHEMBL4869059)
Affinity DataIC50: 42nMAssay Description:Inhibition of PDGFRbeta (unknown origin) incubated for 30 mins in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50571477(CHEMBL4869059)
Affinity DataIC50: 44nMAssay Description:Inhibition of TEL-FLT3 D835H mutant (unknown origin) expressed in mouse BaF3 cells assessed as antiproliferative activity incubated for 72 hrs by CCK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50571477(CHEMBL4869059)
Affinity DataIC50: 44nMAssay Description:Inhibition of FLT3 ITD/F691L double mutant (unknown origin) expressed in mouse BaF3 cells assessed as antiproliferative activity incubated for 72 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50571477(CHEMBL4869059)
Affinity DataIC50: 80nMAssay Description:Inhibition of PDGFRalpha (unknown origin) incubated for 30 mins in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50571477(CHEMBL4869059)
Affinity DataIC50: 120nMAssay Description:Inhibition of VEGFR1 (unknown origin) incubated for 30 mins in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50571477(CHEMBL4869059)
Affinity DataIC50: 137nMAssay Description:Inhibition of VEGFR2 (unknown origin) incubated for 30 mins in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50571477(CHEMBL4869059)
Affinity DataIC50: 716nMAssay Description:Inhibition of CSF1R (unknown origin) incubated for 30 mins in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50571477(CHEMBL4869059)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of c-KIT (unknown origin) incubated for 30 mins in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed