BDBM50572364 CHEMBL4862231

SMILES CC(C)n1cc(cn1)-c1nc(Nc2ccc3N(CCc3c2)S(=O)(=O)c2ccc(cc2)C(F)(F)F)ncc1C

InChI Key InChIKey=CPAHREFSCZMQCN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50572364   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50572364(CHEMBL4862231)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human TYK2 (875 to end residues) using GGMEDIYFEFMGG as substrate incubated for 40 mins in presence of [gamma33P]ATP by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50572364(CHEMBL4862231)
Affinity DataIC50: 82nMAssay Description:Inhibition of recombinant human JAK2 (808 to end residues) KTFCGTPEYLAPE as substrate measured after 40 mins in presence of [gamm33P]ATP by scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50572364(CHEMBL4862231)
Affinity DataIC50: 341nMAssay Description:Inhibition of human JAK1 (866 to end residues) using GEEPLYWSFPAKKK as substrate after 40 mins in presence of [gamma33P]ATP by scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50572364(CHEMBL4862231)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human JAK3 (781 to end residues) using GGEEEEYFELVKKKK as substrate measured after 40 mins in presence of [gamma33P]ATP by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed