BDBM50572380 CHEMBL4876711

SMILES CCCn1cc(cn1)-c1nc(Nc2ccc3N(CCc3c2)S(=O)(=O)c2ccc(cc2)C(F)(F)F)ncc1C

InChI Key InChIKey=YJPMAGFUNAYSMN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50572380   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50572380(CHEMBL4876711)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant human TYK2 (875 to end residues) using GGMEDIYFEFMGG as substrate incubated for 40 mins in presence of [gamma33P]ATP by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50572380(CHEMBL4876711)
Affinity DataIC50: 108nMAssay Description:Inhibition of recombinant human JAK2 (808 to end residues) KTFCGTPEYLAPE as substrate measured after 40 mins in presence of [gamm33P]ATP by scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed