BDBM50572389 CHEMBL4853438

SMILES Fc1cnc(Nc2ccc3N(CCc3c2)S(=O)(=O)c2ccc(cc2)C(F)(F)F)nc1-c1cnn(CCC#N)c1

InChI Key InChIKey=YBMFRJZLSHFEAI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50572389   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50572389(CHEMBL4853438)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant human TYK2 (875 to end residues) using GGMEDIYFEFMGG as substrate incubated for 40 mins in presence of [gamma33P]ATP by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50572389(CHEMBL4853438)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant human JAK2 (808 to end residues) KTFCGTPEYLAPE as substrate measured after 40 mins in presence of [gamm33P]ATP by scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed