BDBM50573317 CHEMBL4846373

SMILES COC(=O)c1cccc(COc2c(oc3ccccc3c2=O)-c2ccc(OCCOCCOCCn3cc(CCN4C(=O)c5ccccc5C4=O)nn3)cc2)c1

InChI Key InChIKey=ISSUHNSOTDYFAQ-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50573317   

TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50573317(CHEMBL4846373)
Affinity DataEC50:  160nMAssay Description:Inhibition of BCRP (unknown origin) transfected in HEK293/R2 cells assessed as reversal of topotecan resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50573317(CHEMBL4846373)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of MRP1 (unknown origin) expressed in human 2008/MRP1 cells assessed as reversal of doxorubicin resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Hong Kong Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50573317(CHEMBL4846373)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of P-gp (unknown origin) expressed in human LCC6MDR cells assessed as reversal of paclitaxel resistance after 5 days by MTS/PMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed