BDBM50573696 CHEMBL4877277

SMILES [H][C@@]12CCCN1C(=O)CCCCCCCOc1ccc(C[C@H](NC2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)[C@@]2(C)CO2)cc1

InChI Key InChIKey=KDMVHKJIOZDWAT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50573696   

TargetProteasome subunit beta type-9(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50573696(CHEMBL4877277)
Affinity DataIC50: 33nMAssay Description:Inhibition of human 20S proteasome LMP2 activity in human RPMI-8226 cells using Ac-PAL-AMC as fluorogenic substrate incubated for 72 hrs by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetProteasome subunit beta type-9(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50573696(CHEMBL4877277)
Affinity DataIC50: 106nMAssay Description:Inhibition of human 20S proteasome LMP2 activity in human RPMI-8226 cells overexpressing ABCB1 using Ac-PAL-AMC as fluorogenic substrate incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetProteasome subunit beta type-9(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50573696(CHEMBL4877277)
Affinity DataIC50: 184nMAssay Description:Inhibition of human 20S proteasome LMP2 using Ac-PAL-AMC as fluorogenic substrate measured every minute for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetProteasome subunit beta type-9(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50573696(CHEMBL4877277)
Affinity DataIC50: 184nMAssay Description:Inhibition of human LMP2 using Ac-PAL-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 90 min by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50573696(CHEMBL4877277)
Affinity DataIC50: 399nMAssay Description:Inhibition of human 20S proteasome LMP7 using Ac-ANW-AMC as fluorogenic substrate measured every minute for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed