BDBM50575173 CHEMBL4847050::US12065436, Compound 184

SMILES CCc1nc(no1)-c1ccc2[C@@H](CCc2c1)NC(=O)c1cnn(C)c1

InChI Key InChIKey=IOVAZWDIRCRMTM-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50575173   

TargetMyosin-1(Bovine)
Cytokinetics

US Patent
LigandPNGBDBM50575173(CHEMBL4847050 | US12065436, Compound 184)
Affinity DataIC50: 1.40E+3nMAssay Description:To evaluate the effect of compounds on the ATPase activity of full-length cardiac myosin in the context of the native sarcomere, skinned myofibril as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
Go to US Patent

TargetCytochrome P450 2C19(Human)
Cytokinetics

Curated by ChEMBL
LigandPNGBDBM50575173(CHEMBL4847050 | US12065436, Compound 184)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C19 in human liver microsomes assessed as mephenytoin 4-hydroxylation reaction incubated for 30 mins in presence of NADP by LC-MS/M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Cytokinetics

Curated by ChEMBL
LigandPNGBDBM50575173(CHEMBL4847050 | US12065436, Compound 184)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as bufuralol 1'-hydroxylation reaction incubated for 30 mins in presence of NADP by LC-MS/MS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Cytokinetics

Curated by ChEMBL
LigandPNGBDBM50575173(CHEMBL4847050 | US12065436, Compound 184)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as midazolam 1'-hyrozylation reaction incubated for 30 mins in presence of NADP by LC-MS/MS a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Cytokinetics

Curated by ChEMBL
LigandPNGBDBM50575173(CHEMBL4847050 | US12065436, Compound 184)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as testosterone 6-beta-hydroxylation reaction incubated for 30 mins in presence of NADP by LC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A5(Human)
Cytokinetics

Curated by ChEMBL
LigandPNGBDBM50575173(CHEMBL4847050 | US12065436, Compound 184)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A5 in human liver microsomes incubated for 30 mins in presence of NADP by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Cytokinetics

Curated by ChEMBL
LigandPNGBDBM50575173(CHEMBL4847050 | US12065436, Compound 184)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2 in human liver microsomes assessed as phenacetin O-deethylation reaction incubated for 30 mins in presence of NADP by LC-MS/MS a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Cytokinetics

Curated by ChEMBL
LigandPNGBDBM50575173(CHEMBL4847050 | US12065436, Compound 184)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as bupropion hydroxylation reaction incubated for 30 mins in presence of NADP by LC-MS/MS ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Cytokinetics

Curated by ChEMBL
LigandPNGBDBM50575173(CHEMBL4847050 | US12065436, Compound 184)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C8 in human liver microsomes assessed as paclitaxel 6a-hydroxylation reaction incubated for 30 mins in presence of NADP by LC-MS/MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Cytokinetics

Curated by ChEMBL
LigandPNGBDBM50575173(CHEMBL4847050 | US12065436, Compound 184)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as diclofenac 4'-hydroxylation reaction incubated for 30 mins in presence of NADP by LC-MS/MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed