BDBM50575339 CHEMBL4869384

SMILES NS(=O)(=O)N1CCC2(CC1)[C@H](c1cc(ccn1)-c1ccccc1)C2(F)F

InChI Key InChIKey=OPNGXZAAMZYOTC-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50575339   

TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 50575339BDBM50575339(CHEMBL4869384 | US12534458, Example A1)
Affinity DataEC50:  190nMAssay Description:mGluR5 activity was determined in a cell-based assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2026
Entry Details US Patent

TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 50575339BDBM50575339(CHEMBL4869384 | US12534458, Example A1)
Affinity DataEC50:  190nMAssay Description:Positive allosteric modulation of human nAChRalpha7 expressed in HEK cells co-expressing RIC3 assessed as effect on acetylcholine-evoked current by p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed