BDBM50575476 CHEMBL4853421

SMILES OC(=O)CNCCn1nnc(n1)-c1ccc(Oc2ccc(Cl)cc2)cc1

InChI Key InChIKey=LURSKVUJDNYDPG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50575476   

TargetLeukotriene A-4 hydrolase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50575476(CHEMBL4853421)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged LTA4H (unknown origin) expressed in Escherichia coli BL21 DE3 cells at enzyme concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50575476(CHEMBL4853421)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of LTA4H in human whole blood assessed as reduction of calcium ionophore A23187-stimulated LTB4 generation preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50575476(CHEMBL4853421)
Affinity DataIC50: 3.00E+4nMAssay Description:Displacement of [3H]dofetilide from recombinant human ERG stably expressed in HEK293 cell membranes measured after 90 mins by microbeta liquid scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed