BDBM50576231 CHEMBL4860509

SMILES CCOC(=O)c1cc(C)cc(NNC(=O)Nc2cc(Cl)nc(Cl)c2)n1

InChI Key InChIKey=XZOXFDNXNUDTJY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50576231   

TargetSphingosine 1-phosphate receptor 2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50576231(CHEMBL4860509)
Affinity DataIC50: 2.10nMAssay Description:Antagonist activity at recombinant human S1P2 receptor expressed in human CHO cells assessed as EC80 S1P-induced activation incubated for 4 hrs in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50576231(CHEMBL4860509)
Affinity DataIC50: 300nMAssay Description:Displacement of radio labeled-SIP from human recombinant S1P2 receptor expressed in CHO cell membranes measured after 15 mins by radioligand based co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50576231(CHEMBL4860509)
Affinity DataIC50: 760nMAssay Description:Antagonist activity at human S1P2 receptor expressed in CHO cells assessed as EC80 S1P-induced calcium flux measured for 3 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50576231(CHEMBL4860509)
Affinity DataIC50: 2.30E+4nMAssay Description:Agonist activity at human S1P2 receptor expressed in CHO cells assessed as calcium flux measured for 3 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed