BDBM50576761 CHEMBL4860278

SMILES OC[C@@H](O[C@H]1CCCN(Cc2ccc(cc2)C(O)=O)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1

InChI Key InChIKey=IGWIUKYUKCCQNT-UHFFFAOYSA-N

Data  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50576761   

TargetcGMP-dependent protein kinase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50576761(CHEMBL4860278)
Affinity DataEC50:  1.10E+4nMAssay Description:Activation of cGMP induced partially activated state recombinant PKG1alpha (unknown origin) using Glass-tide peptide substrate incubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50576761(CHEMBL4860278)
Affinity DataEC50:  1.10E+4nMAssay Description:Activation of full length PKG1alpha (unknown origin) using Glass-tide peptide substrate incubated for 120 mins followed by addition of ADP-Glo max re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50576761(CHEMBL4860278)
Affinity DataEC50:  1.50E+4nMAssay Description:Activation of PKG1alpha in human HEK293 cells stably expressing VASP assessed as VSAP phosphorylation at Ser 239 incubated for 45 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50576761(CHEMBL4860278)
Affinity DataEC50:  1.50E+4nMAssay Description:Activation of PKG1alpha (unknown origin) in human HEK293 cellls assessed as VSAP phosphorylation at Ser 239 incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50576761(CHEMBL4860278)
Affinity DataEC50:  7.70E+4nMAssay Description:Activation of basal state recombinant PKG1alpha (unknown origin) using Glass-tide peptide substrate incubated for 30 mins followed by ATP addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed