BDBM50576794 CHEMBL4866153

SMILES CNC(=O)c1ccc2CC3(Cc2c1)N(C)C(=S)N(C3=O)c1ccc(C#N)c(c1)C(F)(F)F

InChI Key InChIKey=KJNFUKYWWSXYPS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50576794   

TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50576794(CHEMBL4866153)
Affinity DataIC50: 525nMAssay Description:Antagonist activity at AR F877L mutant (unknown origin) transfected in human LNCAP cells assessed as inhibition of R1881-stimulated receptor transcri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50576794(CHEMBL4866153)
Affinity DataIC50: 646nMAssay Description:Antagonist activity at wild type androgen receptor in castration-resistant human LNCaP cells assessed as inhibition of R1881-stimulated receptor tran...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed