BDBM50579542 CHEMBL4878408
SMILES COc1ccc(cc1OC(C(C)C)C(=O)NO)N(C)c1nc(C)nc2ccccc12
InChI Key InChIKey=ZTYHIBVAHSWEEK-UHFFFAOYSA-N
Data 17 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50579542
TargetHistone deacetylase 1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HDAC1 (unknown origin) using Ac-peptide-AMC as substrate incubated for 1 hr by fluorescence methodMore data for this Ligand-Target Pair
TargetCytochrome P450 2E1(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 6.92E+4nMAssay Description:Inhibition of CYP2E1 in human liver microsomes using probe substrate in presence of NADPH regenerating system incubated for 60 mins by UFLC-MS/MS ana...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human HDAC2 using Ac-peptide-AMC as substrate incubated for 1 hr by fluorescence methodMore data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of C-terminal His-tagged recombinant human HDAC3 (1 to 428 residues)/N-terminal GST-tagged recombinant human NCoR2 (395 to 489 residues) c...More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged/C-terminal His-tagged human HDAC4 (627 to 1084 residues) expressed in baculovirus expression system using Ac-pept...More data for this Ligand-Target Pair
TargetHistone deacetylase 5(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC5 (627 to 1084 residues) expressed in baculovirus expression system using Ac-peptide-AMC as...More data for this Ligand-Target Pair
TargetHistone deacetylase 7(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC7 (518 to end residues) expressed in baculovirus expression system using Ac-peptide-AMC as ...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of C-terminal GST-tagged full length human HDAC8 (518 to end residues) expressed in baculovirus expression system using Ac-peptide-AMC as ...More data for this Ligand-Target Pair
TargetHistone deacetylase 9(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of C-terminal GST-tagged full length human HDAC9 (604 to 1066 residues) expressed in baculovirus expression system using Ac-peptide-AMC as...More data for this Ligand-Target Pair
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged full length human HDAC10 (2 to 631 residues) expressed in baculovirus infected sf9 cells using Ac-peptide-AMC as...More data for this Ligand-Target Pair
TargetHistone deacetylase 11(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of N-terminal FLAG-tagged full length human HDAC11 expressed in baculovirus infected sf9 cells using Ac-peptide-AMC as substrate incubated...More data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 1.68E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using probe substrate in presence of NADPH regenerating system incubated for 60 mins by UFLC-MS/MS ana...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using probe substrate in presence of NADPH regenerating system incubated for 60 mins by UFLC-MS/MS ana...More data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using probe substrate in presence of NADPH regenerating system incubated for 60 mins by UFLC-MS/MS an...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: 9.28E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using probe substrate in presence of NADPH regenerating system incubated for 60 mins by UFLC-MS/MS ana...More data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using probe substrate in presence of NADPH regenerating system incubated for 60 mins by UFLC-MS/MS ana...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by ChEMBL
West China Hospital Of Sichuan University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HDAC6 (unknown origin) using Ac-peptide-AMC as substrate incubated for 1 hr by fluorescence methodMore data for this Ligand-Target Pair