BDBM50579659 CHEMBL5088848

SMILES COCCNC(=O)c1cccc(Nc2nc(C)c(s2)-c2cc3CN([C@@H](C)C4CC4)C(=O)c3c(c2)S(C)(=O)=O)n1

InChI Key InChIKey=FLNSZPSGBYDYIC-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50579659   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50579659(CHEMBL5088848)Copy SMILESCopy InChI

Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human PI3Kgamma assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/4/2023
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50579659(CHEMBL5088848)Copy SMILESCopy InChI

Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/4/2023
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL