BDBM50581522 CHEMBL5075273

SMILES Cn1cc(cn1)-c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F

InChI Key InChIKey=YEQLIQZCYJPPOO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50581522   

TargetHigh affinity nerve growth factor receptor(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50581522(CHEMBL5075273)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of wildtype TRKA (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 40 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50581522(CHEMBL5075273)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of TRKA GS95R mutant (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50581522(CHEMBL5075273)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of TRKA G595R mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50581522(CHEMBL5075273)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of wild type TRKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50581522(CHEMBL5075273)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50581522(CHEMBL5075273)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed