BDBM50581792 CHEMBL5093813

SMILES c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@H]4[C@H](O3)COP(=O)(O[C@@H]5[C@@H](COP(=O)(O4)O)O[C@H]([C@@H]5F)n6cnc7c6ncnc7N)O)F)N

InChI Key InChIKey=LMPBRGUYJGJYOI-UHFFFAOYSA-N

Data  5 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50581792   

TargetStimulator of interferon genes protein(Human)
Institute of Organic Chemistry and Biochemistry of The Czech Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50581792BDBM50581792(CHEMBL5093813)
Affinity DataEC50:  20nMAssay Description:Activation of wild-type human STING expressed in digitonin treated HEK293T cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetStimulator of interferon genes protein(Human)
Institute of Organic Chemistry and Biochemistry of The Czech Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50581792BDBM50581792(CHEMBL5093813)
Affinity DataEC50:  1.03E+3nMAssay Description:Activation of wild-type human STING expressed in human THP1-Dual cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activation measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetStimulator of interferon genes protein(Human)
Institute of Organic Chemistry and Biochemistry of The Czech Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50581792BDBM50581792(CHEMBL5093813)
Affinity DataEC50:  7.99E+3nMAssay Description:Activation of wild-type human STING expressed in HEK293T cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activation measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetStimulator of interferon genes protein(Human)
Institute of Organic Chemistry and Biochemistry of The Czech Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50581792BDBM50581792(CHEMBL5093813)
Affinity DataEC50:  1.91E+4nMAssay Description:Activation of wild-type human STING expressed in digitonin treated human THP1-Dual cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetStimulator of interferon genes protein(Human)
Institute of Organic Chemistry and Biochemistry of The Czech Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50581792BDBM50581792(CHEMBL5093813)
Affinity DataEC50:  9.65E+4nMAssay Description:Activation of wild-type human STING expressed in HEK293T cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activation measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)