BDBM50582040 CHEMBL5083660

SMILES CN(C)CCN1CCC(CC1)n1nnc(C)c1-c1cccc(Oc2cc(C)cc(C)c2)n1

InChI Key InChIKey=PIKWYDHWUKSWAQ-UHFFFAOYSA-N

Data  1 KI  6 IC50  9 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50582040   

TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582040BDBM50582040(CHEMBL5083660)
Affinity DataKd:  12nMAssay Description:Binding affinity to human partial length BRD4 BD1 expressed in bacterial expression system assessed as dissociation constant by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582040BDBM50582040(CHEMBL5083660)
Affinity DataKd:  12nMAssay Description:Binding affinity to BRD4 BD1 (unknown origin) assessed as dissociation constant by Discover X assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBromodomain testis-specific protein(Human)
University of Minnesota

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582040BDBM50582040(CHEMBL5083660)
Affinity DataKd:  15nMAssay Description:Binding affinity to human partial length BRDT BD1 expressed in bacterial expression system assessed as dissociation constant by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
University of Minnesota

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582040BDBM50582040(CHEMBL5083660)
Affinity DataKd:  20nMAssay Description:Binding affinity to human partial length BRD3 BD1 expressed in bacterial expression system assessed as dissociation constant by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Minnesota

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582040BDBM50582040(CHEMBL5083660)
Affinity DataKd:  22nMAssay Description:Binding affinity to human partial length BRD2 BD1 expressed in bacterial expression system assessed as dissociation constant by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582040BDBM50582040(CHEMBL5083660)
Affinity DataIC50: 29nMAssay Description:Inhibition of human his tagged BRD4-BD2 using Histone H4 peptide (1-21) K5/8/12/16Ac as substrate preincubated for 30 mins followed by addition of bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582040BDBM50582040(CHEMBL5083660)
Affinity DataIC50: 39nMAssay Description:Inhibition of his9-tagged BRD4-BD1 (unknown origin) preincubated for 30 mins followed by addition of biotinylated peptide and measured after 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582040BDBM50582040(CHEMBL5083660)
Affinity DataKi:  63nMAssay Description:Binding affinity to N-luc fused BRD4-BD1 in HEK293T cells assessed as apparent inhibition constant using NanoGlo substrate as substrate incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582040BDBM50582040(CHEMBL5083660)
Affinity DataKd:  67nMAssay Description:Binding affinity to human partial length BRD4 BD2 expressed in bacterial expression system assessed as dissociation constant by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582040BDBM50582040(CHEMBL5083660)
Affinity DataIC50: 137nMAssay Description:Binding affinity to BRD4 BD1 (unknown origin) by fluorescence anisotropy methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582040BDBM50582040(CHEMBL5083660)
Affinity DataEC50:  160nMAssay Description:Inhibition of N-luc fused BRD4-BD1 in HEK293T cells using NanoGlo substrate as substrate incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
University of Minnesota

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582040BDBM50582040(CHEMBL5083660)
Affinity DataKd:  200nMAssay Description:Binding affinity to human partial length BRD2 BD2 expressed in bacterial expression system assessed as dissociation constant by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Minnesota

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582040BDBM50582040(CHEMBL5083660)
Affinity DataIC50: 240nMAssay Description:Inhibition of his9-tagged BRD2-BD2 (unknown origin) preincubated for 30 mins followed by addition of biotinylated peptide and measured after 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetBromodomain testis-specific protein(Human)
University of Minnesota

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582040BDBM50582040(CHEMBL5083660)
Affinity DataKd:  250nMAssay Description:Binding affinity to human partial length BRDT BD2 expressed in bacterial expression system assessed as dissociation constant by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
University of Minnesota

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582040BDBM50582040(CHEMBL5083660)
Affinity DataKd:  310nMAssay Description:Binding affinity to human partial length BRD3 BD2 expressed in bacterial expression system assessed as dissociation constant by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582040BDBM50582040(CHEMBL5083660)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of BRD4-BD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582040BDBM50582040(CHEMBL5083660)
Affinity DataIC50: 1.02E+3nMAssay Description:Binding affinity to BRD4 BD2 (unknown origin) by fluorescence anisotropy methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed