BDBM50582559 CHEMBL5093894

SMILES CN1CCN(CC1)[C@H]1CC(F)(F)c2cc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)ccc12

InChI Key InChIKey=BPLVEFPXYUJTQJ-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50582559   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Peking Union Medical College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582559BDBM50582559(CHEMBL5093894)
Affinity DataIC50: 10nMAssay Description:Inhibition of human c-SRC using poly [Glu:Tyr] as substrate incubated for 30 mins followed by 33P-ATP addition and measured after 2 hrs by liquid sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Peking Union Medical College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582559BDBM50582559(CHEMBL5093894)
Affinity DataIC50: 10nMAssay Description:Inhibition of human FGFR1 using KKKSPGEYVNIEFG as substrate incubated for 30 mins followed by 33P-ATP addition and measured after 2 hrs by liquid sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Peking Union Medical College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582559BDBM50582559(CHEMBL5093894)
Affinity DataIC50: 10nMAssay Description:Inhibition of human FLT3 using EAIYAAPFAKKK as substrate incubated for 30 mins followed by 33P-ATP addition and measured after 2 hrs by liquid scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Peking Union Medical College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582559BDBM50582559(CHEMBL5093894)
Affinity DataIC50: 10nMAssay Description:Inhibition of human KDR/VEGFR2 using poly [Glu:Tyr] as substrate incubated for 30 mins followed by 33P-ATP addition and measured after 2 hrs by liqui...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Peking Union Medical College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582559BDBM50582559(CHEMBL5093894)
Affinity DataIC50: 10nMAssay Description:Inhibition of human LYN using poly [Glu:Tyr] as substrate incubated for 30 mins followed by 33P-ATP addition and measured after 2 hrs by liquid scint...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Peking Union Medical College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582559BDBM50582559(CHEMBL5093894)
Affinity DataIC50: 10nMAssay Description:Inhibition of human PDGFRa using poly [Glu:Tyr] as substrate incubated for 30 mins followed by 33P-ATP addition and measured after 2 hrs by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Peking Union Medical College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582559BDBM50582559(CHEMBL5093894)
Affinity DataIC50: 22nMAssay Description:Inhibition of FGFR1 (unknown origin) using FAM-P22 peptide as substrate preincubated with compound for 10 mins followed by substrate addition and ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Peking Union Medical College and Chinese Academy of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582559BDBM50582559(CHEMBL5093894)
Affinity DataIC50: 22nMAssay Description:Inhibition of FGFR2 (unknown origin) using FAM-P22 peptide as substrate preincubated with compound for 10 mins followed by substrate addition and ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Peking Union Medical College and Chinese Academy of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582559BDBM50582559(CHEMBL5093894)
Affinity DataIC50: 52nMAssay Description:Inhibition of FGFR3 (unknown origin) using FAM-P22 peptide as substrate preincubated with compound for 10 mins followed by substrate addition and ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Peking Union Medical College and Chinese Academy of Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582559BDBM50582559(CHEMBL5093894)
Affinity DataIC50: 124nMAssay Description:Inhibition of FGFR4 (unknown origin) using FAM-P22 peptide as substrate preincubated with compound for 10 mins followed by substrate addition and ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Peking Union Medical College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582559BDBM50582559(CHEMBL5093894)
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed