BDBM50583332 CHEMBL5079859

SMILES CNC(=O)[C@H]1CC[C@@]2(CNc3ncc(c(Cl)c23)-c2ccc(N)c(C(=O)N(C)C)c2F)C1

InChI Key InChIKey=LDUCKJFAEAZQCE-UHFFFAOYSA-N

Data  1 KI  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50583332   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Genentech

Curated by ChEMBL

LigandBDBM50583332(CHEMBL5079859)Copy SMILESCopy InChI

Affinity DataKi:  63nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/6/2023
Entry Details Article
Copy BDB DOIPubMed
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TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Genentech

Curated by ChEMBL

LigandBDBM50583332(CHEMBL5079859)Copy SMILESCopy InChI

Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of HPK1 in human Jurkat E6.1 cells assessed as SLP76 phosphorylation incubated for 30 mins followed by anti-CD3, biotinylated anti-SLP76 a...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/6/2023
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL