BDBM50583335 CHEMBL5087625

SMILES CN(C)C(=O)c1c(N)ccc(c1F)-c1cnc2NC[C@@]3(CC[C@@H](C3)c3ncn[nH]3)c2c1Cl

InChI Key InChIKey=WIGROTXXZJZZAY-UHFFFAOYSA-N

Data  1 KI  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50583335   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Genentech

Curated by ChEMBL

LigandBDBM50583335(CHEMBL5087625)Copy SMILESCopy InChI

Affinity DataKi:  14nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/6/2023
Entry Details Article
Copy BDB DOIPubMed
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TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Genentech

Curated by ChEMBL

LigandBDBM50583335(CHEMBL5087625)Copy SMILESCopy InChI

Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of HPK1 in human Jurkat E6.1 cells assessed as SLP76 phosphorylation incubated for 30 mins followed by anti-CD3, biotinylated anti-SLP76 a...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/6/2023
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL