BDBM50583337 CHEMBL5081453

SMILES CN(C)C(=O)c1c(N)ccc(c1F)-c1cnc2NC[C@@]3(CC[C@]4(C3)CCCCNC4=O)c2c1Cl

InChI Key InChIKey=BQNOSQCCTRPINT-UHFFFAOYSA-N

Data  1 KI  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50583337   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Genentech

Curated by ChEMBL

LigandBDBM50583337(CHEMBL5081453)Copy SMILESCopy InChI

Affinity DataKi:  7.20nMAssay Description:Inhibition of HPK1 (unknown origin) preincubated for 30 mins with compound followed by Biotin-SLP-76 substrate in presence of ATP incubated for 60 mi...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/6/2023
Entry Details Article
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TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Genentech

Curated by ChEMBL

LigandBDBM50583337(CHEMBL5081453)Copy SMILESCopy InChI

Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of HPK1 in human Jurkat E6.1 cells assessed as SLP76 phosphorylation incubated for 30 mins followed by anti-CD3, biotinylated anti-SLP76 a...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/6/2023
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL