BDBM50583338 CHEMBL5088939

SMILES CCc1c[nH]c2ncc(cc12)-c1ccc(N)c(c1)C(=O)N(C)C

InChI Key InChIKey=LZYWVOKHWFMDJU-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50583338   

LigandPNGBDBM50583338(CHEMBL5088939)
Affinity DataKi:  2.10nMAssay Description:Inhibition of HPK1 (unknown origin) followed by anti-GST antibody incubated for 60 mins measured after 1 hr by TR-FRET based LanthaScreen Eu-Kinase b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50583338(CHEMBL5088939)
Affinity DataIC50: 22nMAssay Description:Inhibition of Abl I (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50583338(CHEMBL5088939)
Affinity DataIC50: 500nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate by TDI- high-throughput based mass spectrometry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed